Curve Fitting Algorithm-Based Contrast-Enhanced Ultrasound Image for Evaluating the Effect of Dexmedetomidine on Neurological Function in Patients Undergoing Brain Tumor Surgery

Abstract

Objective. The study aimed to explore the influence of dexmedetomidine (Dex) guided by ultrasonic contrast on postoperative cognitive function, serum nerve injury factors, inflammatory response, and blood glucose in patients undergoing intracerebral tumor resection through curve fitting algorithm. Methods. 80 patients who underwent tumor resection were selected and randomly rolled into control (Ctrl) group and Dex group, with 40 in each. Then, patients in the Dex group received 0.4 μg/kg⋅h Dex, and patients in Ctrl received the same amount of normal saline. Both groups were diagnosed with benign or malignant tumors by contrast-enhanced ultrasound (CEUS) based on time-intensity curve (TIC) before surgery. Cognitive Capacity Screening Examination (CCSE) and Montreal Cognitive Assessment (MoCA) were used to assess the cognitive function 1 day before and 3 days after the operation, and the ELISA method was used to detect levels of nerve damage-related factors and inflammation factor. Finally, the fasting blood glucose (FBG) levels were detected at the same time. Results. In contrast with benign lesions, the AUC, MTT, and PI of malignant lesions were obviously reduced ( $P<0.05$ ), while TP was obviously increased ( $P<0.05$ ). The postoperative CCSE and MoCA scores of the Dex group were obviously higher than Ctrl ( $P<0.05$ ). In contrast with the Ctrl, the CCSE and MoCA scores in the Dex group increased obviously after 3 days ( $P<0.05$ ). In addition, the incidence of postoperative cognitive dysfunction (POCD) in the Dex group was obviously reduced ( $P<0.05$ ). Besides, levels of S100β, NSE, and GFAP were obviously reduced in the Dex group 1 day after surgery ( $P<0.05$ ), while levels of IL-6 and TNF-α were obviously reduced ( $P<0.05$ ), and returned to the level of Ctrl 3 days after surgery. There was no obvious difference in FBG at each time point between the two. Conclusion. CEUS based on curve fitting algorithm is effective on nursing treatment of intracranial tumors. Dex can obviously improve POCD and reduce levels of serum nerve injury factors and inflammatory factors.