Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications-Reference-Cited by-同舟云学术

Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications

Published:2016 Issue: Volume:2016 Page:1-9
ISSN:1687-966X
Container-title:Stem Cells International
language:en
Short-container-title:Stem Cells International

Author:

Choudry Fizzah Aziz¹²,Frontini Mattia¹²³

Affiliation:

1. Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK

2. National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK

3. British Heart Foundation Centre of Excellence, University of Cambridge, Cambridge CB2 0QQ, UK

Abstract

Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications.

Publisher

Hindawi Limited

Subject

Cell Biology,Molecular Biology

Link

http://downloads.hindawi.com/journals/sci/2016/5797521.pdf

Reference100 articles.

1. Hematopoietic Stem Cells

2. Diversity of haematopoietic stem cell growth from a uniform population of cells

3. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness

4. Stem cells, cancer, and cancer stem cells

5. Stem and Progenitor Cells: Origins, Phenotypes, Lineage Commitments, and Transdifferentiations

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