Is It Time to Beta Block the Septic Patient?-Reference-Cited by-同舟云学术

Is It Time to Beta Block the Septic Patient?

Published:2015 Issue: Volume:2015 Page:1-6
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Pemberton Philip¹,Veenith Tonny¹²³,Snelson Catherine¹,Whitehouse Tony¹⁴^ORCID

Affiliation:

1. Department of Anaesthesia and Critical Care Medicine, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham B15 2GW, UK

2. Department of Infection and Inflammation, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

3. Department of Medicine, University of Cambridge, The Old Schools, Trinity Lane, Cambridge CB2 1TN, UK

4. College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Abstract

Beta blockers are some of the most studied drugs in the pharmacopoeia. They are already widely used in medicine for treating hypertension, chronic heart failure, tachyarrhythmias, and tremor. Whilst their use in the immediate perioperative patient has been questioned, the use of esmolol in the patients with established septic shock has been recently reported to have favourable outcomes. In this paper, we review the role of the adrenergic system in sepsis and the evidence for the use of beta stimulation and beta blockers from animal models to critically ill patients.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2015/424308.pdf

Reference64 articles.

1. Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock

2. Mechanisms of sepsis-induced cardiac dysfunction

3. Thermal injury and sepsis modulates β-adrenergic receptors and cAMP reponses in monocyte-committed bone marrow cells

4. Bone Marrow Norepinephrine Mediates Development of Functionally Different Macrophages After Thermal Injury and Sepsis

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