The Effects of Secretory IgA in the Mucosal Immune System-Reference-Cited by-同舟云学术

The Effects of Secretory IgA in the Mucosal Immune System

Published:2020-01-08 Issue: Volume:2020 Page:1-6
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Li Yue¹²^ORCID,Jin Liang²³,Chen Tongxin¹²^ORCID

Affiliation:

1. Department of Rheumatology/Immunology, Children’s National Medical Center, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. Division of Immunology, Institute of Pediatric Translational Medicine, Children’s National Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3. Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Abstract

Immunoglobulin A (IgA) is the most abundant antibody isotype in the mucosal immune system. Structurally, IgA in the mucosal surface is a polymeric structure, while serum IgA is monomeric. Secretory IgA (sIgA) is one of the polymeric IgAs composed of dimeric IgA, J chain, and secretory component (SC). Most of sIgAs were generated by gut and have effects in situ. Besides the function of “immune exclusion,” a nonspecific immune role, recent studies found it also played an important role in the specific immunity and immunoregulation. Thanks to the critical role of sIgA during the mucosal immune system homeostasis between commensal microorganisms and pathogens; it has been an important field exploring the relationship between sIgA and commensal microorganisms.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2020/2032057.pdf

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