Potential Benefits of Therapeutic Use ofβ2-Adrenergic Receptor Agonists in Neuroprotection and Parkinson’s Disease-Reference-Cited by-同舟云学术

Potential Benefits of Therapeutic Use ofβ2-Adrenergic Receptor Agonists in Neuroprotection and Parkinson’s Disease

Published:2014 Issue: Volume:2014 Page:1-8
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Peterson Lynda¹^ORCID,Ismond Kathleen P.²,Chapman Elisha²,Flood Patrick²³

Affiliation:

1. Theralogics, Inc., 1829 E. Franklin Street, Chapel Hill, NC 27514-5861, USA

2. School of Dentistry, University of Alberta, 7020 Katz Group Centre, Edmonton, AB, Canada T6G 2R3

3. North Carolina Oral Health Institute, School of Dentistry, The University of North Carolina at Chapel Hill, Manning Dr. & Columbia Street, Campus Box 7450, Chapel Hill, NC 27599-7450, USA

Abstract

Theβ2-adrenergic receptor (β2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. This review examines the functional dichotomy associated with stimulation ofβ2AR and microglial cells. As well, recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of Parkinson’s disease.

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2014/103780.pdf

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