In Vitro Degradation of PHB/Bacterial Cellulose Biocomposite Scaffolds

Author:

Râpă Maria1,Zaharia Cătălin2ORCID,Stănescu Paul Octavian2,Cășărică Angela3,Matei Ecaterina1,Predescu Andra Mihaela1,Pantilimon Mircea Cristian1,Vidu Ruxandra14,Predescu Cristian1,Cioflan Horia5

Affiliation:

1. University Politehnica of Bucharest, Faculty of Materials Science and Engineering, 313 Splaiul Independentei, 060042 Bucharest, Romania

2. University Politehnica of Bucharest, Advanced Polymer Materials Group, 1-7 Gh. Polizu Str., 011061 Bucharest, Romania

3. National Chemical-Pharmaceutical for Research and Development Institute, Vitan Avenue, No. 112, District 3, Bucharest, Romania

4. University of California Davis, Department of Electrical Engineering, One Shields Avenue, Davis, CA 95616, USA

5. Sanador Clinic Hospital, Sevastopol Street No. 9 Sector 1, Bucharest, Romania

Abstract

The present work reported the preparation of biocomposites based on poly(3-hydroxybutyrate) (PHB), plasticizer, and bacterial cellulose (BC) by melt processing and their testing by means of thermal properties (DSC), water absorption, and in vitro degradation. The surface of the biocomposites was analyzed via atomic force microscopy (AFM). In vitro degradation of the biocomposites was evaluated by weight loss and thermal properties (DSC) assessment after the immersion of the specimens in phosphate-buffered saline solution (PBS of pH 7.4) over 20 days. The results showed that the BC can reduce the PHB crystallinity and promote its degradation under PBS medium. Moreover, it was found that the water absorption increased as the percentage of BC increased.

Funder

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii

Publisher

Hindawi Limited

Subject

Polymers and Plastics

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