Affiliation:
1. Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Abstract
The present work was designed to investigate the antibacterial activities of methanol extracts from six Cameroonian edible plants and their synergistic effects with some commonly used antibiotics against multidrug-resistant (MDR) Gram-negative bacteria expressing active efflux pumps. The extracts were subjected to qualitative phytochemical screening and the microdilution broth method was used for antibacterial assays. The results of phytochemical tests indicate that all tested crude extracts contained polyphenols, flavonoids, triterpenes, and steroids. Extracts displayed selective antibacterial activities with the minimal inhibitory concentration (MIC) values ranging from 32 to 1024 μg/mL. The lowest MIC value (32 μg/mL) was recorded withCoula edulisextract againstE. coliAG102 andK. pneumoniaeK2 and withMangifera indicabark extract againstP. aeruginosaPA01 andCitrus sinensisextract againstE. coliW3110 which also displayed the best MBC (256 μg/mL) value againstE. coliATCC8739. In combination with antibiotics, extracts fromM. indicaleaves showed synergistic effects with 75% (6/8) of the tested antibiotics against more than 80% of the tested bacteria. The findings of the present work indicate that the tested plants may be used alone or in combination in the treatment of bacterial infections including the multidrug-resistant bacteria.
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
37 articles.
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