The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice

Author:

Fan Kai-Jian12,Li Yun-Wu1,Wu Jing1,Li Jun3,Zhang Jun4,Wang Qi-Shan1,Xu Bing-Xin1,Cai Qing5ORCID,Wang Ting-Yu1ORCID

Affiliation:

1. Department of Pharmacy, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China

2. Department of Pharmacy, Mental Health Center, Chongming District, Shanghai 202150, China

3. Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA

4. Department of Internal Medicine, Division of Nephrology, University of California at Davis, Davis, CA 95616, USA

5. Department of Immunology and Rheumatology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China

Abstract

Fufang Shatai Heji (STHJ) is a mixture of traditional Chinese medicines, such as Radix Adenophorae, Radix Pseudostellariae, and Radix Astragali. STHJ is commonly used to treat diseases caused by low immune function, for example, Sjögren’s syndrome (SS). The primary objective of this study was to assess the immunopotentiating effect of STHJ using an immunosuppressive mouse model receiving cyclophosphamide (CTX). Following CTX treatment, STHJ was administered by oral gavage for 30 consecutive days. The percentage of specific lymphocyte subpopulations in the spleen was measured by flow cytometry. Levels of inflammatory factors in serum were detected by enzyme-linked immunosorbent assays (ELISAs). The administration of STHJ significantly elevated thymus and spleen indices, increased B cell and natural killer (NK) cell activities, and decreased CD8+ T, CD8+CD122+ T, NKT, and γδT cell activities in the CTX-treated mice. In addition, STHJ upregulated the expression of interleukin- (IL-) 2, IL-6, and tumor necrosis factor-α (TNF-α) and downregulated IL-10 expression in CTX-treated mice. In conclusion, STHJ effectively remitted CTX-induced immunosuppression by modulating the balance of lymphocyte subsets and cytokines. Our results suggest STHJ treatment could be used as an effective therapeutic approach to improve immune function in patients with low immunity.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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