In VivoEvaluation ofGalla chinensisSolution in the Topical Treatment of Dermatophytosis

Author:

Sun Kai1,Song Xu1,Jia RenYong2,Yin Zhongqiong1ORCID,Zou Yuanfeng1,Li Lixia1,Yin Lizi1,He Changliang1,Liang Xiaoxia1,Ye Gang1,Yue Guizhou3,Zhao Xinghong1,Yu Jiankang1

Affiliation:

1. Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China

2. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China

3. College of Science, Sichuan Agricultural University, Ya’an 625014, China

Abstract

Aim. Dermatophytosis is one of the main fungal diseases in humans and animals all over the world.Galla chinensis, a traditional medicine, has various pharmacological effects. The goal of this study was to evaluate the treatment effect ofGalla chinensissolution (GCS) on dermatophytosis-infected dogs (Microsporum canis,Microsporum gypseum, andTrichophyton mentagrophytes, resp.).Methods. The treatment effects of GCS were evaluated by mycological cure rates and clinical score comprised of three indices, including inflammation, hair loss, and lesion scale.Results. The results showed that, in the three models of dermatophytosis, GCS significantly (P<0.05) improved skin lesions and fungal eradication. GCS (10% and 5%) had higher efficacy compared to the positive control (Tujingpi Tincture). The fungal eradication efficacy exceeds 85% after treatment with GCS (10%, 5%, and 2.5%) on day 14.Conclusion. The GCS has antidermatophytosis effect in dogs, which may be a candidate drug for the treatment of dermatophytosis.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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