Single-Blind, Prospective, Randomized Study of Cefmetazole and Cefoxitin in the Treatment of Postcesarean Endometritis-Reference-Cited by-同舟云学术

Single-Blind, Prospective, Randomized Study of Cefmetazole and Cefoxitin in the Treatment of Postcesarean Endometritis

Published:1995 Issue:1 Volume:3 Page:28-33
ISSN:1064-7449
Container-title:Infectious Diseases in Obstetrics and Gynecology
language:en
Short-container-title:Infectious Diseases in Obstetrics and Gynecology

Author:

Chatwani Ashwin¹,Martens Mark²,Grimes David A.³,Chatterjee Molly⁴,Noah Melvin⁵,Stamp-Cole Marion M.⁵,Perry Kimberly T.⁵,the Cefmetazole Study Group

Affiliation:

1. Department of Ob/Gyn/REI, Temple University Hospital, 3401 N. Broad Street, Philadelphia 19140, PA, USA

2. University of Texas Medical Branch at Galveston, TX, USA

3. University of California, San Francisco General Hospital, San Francisco, CA, USA

4. University of New Mexico School of Medicine, Albuquerque, NM, USA

5. Upjohn Company, Kalamazoo, MI, USA

Abstract

Objective: The purpose of this study was to compare the clinical efficacy and safety of cefmetazole given by IV push with that of parenterally administered cefoxitin for the treatment of endometritis following cesarean delivery.Methods: In a single-blind, multicenter, prospective, randomized study, 355 patients with endometritis after cesarean delivery were enrolled and received medication. Administered was either cefmetazole sodium, 2 g by IV push over 1 min q 8 h, or cefoxitin sodium, 2 g IV q 6 h in a 2:1 ratio. The patients were followed for clinical responses and side effects.Results: The cure rate for cefmetazole was 89% and for cefoxitin it was 79% (P = 0.006). The adverse events were similar in both groups.Conclusions: Cefmetazole was significantly more effective than cefoxitin in the treatment of endometritis following cesarean delivery.

Publisher

Hindawi Limited

Subject

Infectious Diseases,Obstetrics and Gynaecology,Dermatology

Link

http://downloads.hindawi.com/journals/idog/1995/356417.pdf

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