The Inhibitory Effect of Clindamycin onLactobacillus in vitro

Abstract

Objective:To evaluate thein vitroeffect of varying concentrations of clindamycin onLactobacillusspp.Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains ofLactobacillus.Results:Clindamycin concentrations between 1.95–31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p> 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studiedLactobacillusstrains was determined as 1000 mg/ml.Conclusion:High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory forLactobacillus.