An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde-Reference-Cited by-同舟云学术

An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

Published:2017 Issue: Volume:2017 Page:1-6
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Desireddy Neha Reddy¹,Glory Arava²,Bhimireddy Krishna Reddy¹,Kurra Yadagiri³,Reddy Ram¹^ORCID

Affiliation:

1. Nifty Labs Pvt. Ltd., Hyderabad 500016, India

2. Sri Venkateswara University, Tirupathi 517502, India

3. Texas A&M University, College Station, TX 77843, USA

Abstract

An efficient synthesis of milnacipran hydrochloride has been accomplished. The important application of this paper is the reductive amination of aldehyde to primary amine with water soluble reagents. This method provides a high yield of primary amine as the major product, reduces the number of steps, and discourages by-products.

Funder

Nifty Labs Pvt. Limited

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2017/5385843.pdf

Reference21 articles.

1. (.+-.)-(Z)-2-(Aminomethyl)-1-phenylcyclopropanecarboxamide Derivatives as a New Prototype of NMDA Receptor Antagonists

2. BuMgNiPr2: A New Base for Stoichiometric, Position-Selective Deprotonation of Cyclopropane Carboxamides and Other Weak CH Acids This work was supported in part by Eastman Chemical. We are grateful to Z. Hantosi and C.-H. Lee for trial experiments, to I. Steele for the X-ray analyses, and to Professor S. Shuto of Hokkaido University for samples of Milnacipran precursors.

3. A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran

4. The Preparation of Glycamines1

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