Affiliation:
1. Cardiothoracic Intensive Care Unit, NUHS, Singapore 119074
2. National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
3. Intensive Care Unit, NUHS, Singapore 119074
Abstract
Sepsis results in widespread inflammatory responses altering homeostasis. Associated circulatory abnormalities (peripheral vasodilation, intravascular volume depletion, increased cellular metabolism, and myocardial depression) lead to an imbalance between oxygen delivery and demand, triggering end organ injury and failure. Fluid resuscitation is a key part of treatment, but there is little agreement on choice, amount, and end points for fluid resuscitation. Over the past few years, the safety of some fluid preparations has been questioned. Our paper highlights current concerns, reviews the science behind current practices, and aims to clarify some of the controversies surrounding fluid resuscitation in sepsis.
Funder
National University Health System Singapore
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
8 articles.
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