Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review-Reference-Cited by-同舟云学术

Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review

Published:2018-07-26 Issue: Volume:2018 Page:1-5
ISSN:2090-6889
Container-title:Case Reports in Rheumatology
language:en
Short-container-title:Case Reports in Rheumatology

Author:

Ikeuchi Hidekazu¹^ORCID,Koinuma Kana¹,Nakasatomi Masao¹^ORCID,Sakairi Toru¹,Kaneko Yoriaki¹,Maeshima Akito¹,Yamazaki Yuichi²,Okamoto Hiroaki³,Mimura Toshihide⁴^ORCID,Mochida Satoshi⁵,Nojima Yoshihisa⁶,Hiromura Keiju¹^ORCID

Affiliation:

1. Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan

2. Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan

3. Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Japan

4. Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

5. Division of Gastroenterology and Hepatology Internal Medicine, Saitama Medical University, Saitama, Japan

6. Department of Rheumatology and Nephrology, Japan Red Cross Maebashi Hospital, Maebashi, Japan

Abstract

Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocilizumab. Analysis of serially stocked serum samples confirmed that hepatitis was caused by primary infection with HEV and not by viral reactivation. Her liver function improved after discontinuing tocilizumab and remained within the normal range without reactivation of HEV for >5 years after restarting tocilizumab. We also reviewed the published cases of hepatitis E that developed during RA treatment.

Publisher

Hindawi Limited

Subject

General Agricultural and Biological Sciences

Link

http://downloads.hindawi.com/journals/crirh/2018/6873276.pdf

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