Occupationally Acquired American Cutaneous Leishmaniasis

Author:

Felinto de Brito Maria Edileuza12,Andrade Maria Sandra3,de Almeida Éricka Lima1,Medeiros Ângela Cristina Rapela4,Werkhäuser Roberto Pereira1,Araújo Ana Isabele Freitas de1,Brandão-Filho Sinval Pinto1,Paiva de Almeida Alzira Maria1,Gomes Rodrigues Eduardo Henrique1

Affiliation:

1. Centro de Pesquisas Aggeu Magalhães, FIOCRUZ-PE, Campus da Universidade Federal de Pernambuco s/n, Cidade Universitária, 50.670-901 Recife, PE, Brazil

2. Centro de Ciências Biológicas, Universidade Federal de Pernambuco s/n, Cidade Universitária, 50.670-901 Recife, PE, Brazil

3. Departamentos de Enfermagem, Universidade de Pernambuco, Rua Arnóbio Marques 310, Santo Amaro, 50.100-130 Recife, PE, Brazil

4. Departamentos de Dermatologia, Universidade de Pernambuco, Rua Arnóbio Marques 310, Santo Amaro, 50.100-130 Recife, PE, Brazil

Abstract

We report two occupationally acquired cases of American cutaneous leishmaniasis (ACL): one accidental laboratory autoinoculation by contaminated needlestick while handling an ACL lesion sample, and one acquired during field studies on bird biology. Polymerase chain reaction (PCR) assays of patient lesions were positive forLeishmania, subgenusViannia. One isolate was obtained by culture (from patient 2 biopsy samples) and characterized asLeishmania(Viannia)naiffithrough an indirect immunofluorescence assay (IFA) with species-specific monoclonal antibodies (mAbs) and by multilocus enzyme electrophoresis (MLEE). Patients were successfully treated with N-methyl-glucamine. These two cases highlight the potential risks of laboratory and field work and the need to comply with strict biosafety procedures in daily routines. The swab collection method, coupled with PCR detection, has greatly improved ACL laboratory diagnosis.

Publisher

Hindawi Limited

Subject

Dermatology

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