Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome

Author:

Zhou Yanyuan1,Lan Huan1,Dong Zhewen1,Li Wanying2,Qian Bo23,Zeng Zhen24,He Wen2,Song Jia-Le2567ORCID

Affiliation:

1. Department of Analytical Chemistry & Drug Analysis, School of Pharmacy, Guilin Medical University, Guilin, 541004 Guangxi, China

2. Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, 541004 Guangxi, China

3. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102 Fujian, China

4. Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, 410078 Hunan, China

5. Department of Clinical Nutrition, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199 Guangxi, China

6. Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin, 541100 Guangxi, China

7. Guangxi Key Laboratory of Environmental Exposureomics and Entire Lifecycle Health, Guilin Medical University, Guilin, 541100 Guangxi, China

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine-related cause of infertility in women and has an unknown etiology. Studies have shown that rhamnocitrin (Rha) exhibits positive effects on the reproductive system. This study investigated Rha’s antifibrotic effects on PCOS rats and revealed its underlying mechanisms. Female SD rats were randomized into 4 groups ( n = 8 , each); the control group received tea oil by intraperitoneal injection and 1% w / v CMC by oral gavage; the PCOS group received letrozole (1 mg/kg); the PCOS+Rha group received letrozole and Rha (5 mg/kg); the PCOS+Met group received letrozole and Met (265 mg/kg) for 21 days. At the study end, Rha treatment restored letrozole-induced alterations in the relative ovarian weights, body weight, and relative weights of uterine and visceral adipose tissues. Histological observation showed that Rha ameliorates ovarian structure and fibrosis in PCOS. Administration of Rha reduced letrozole-induced metabolic dysfunction by ameliorating the levels of TC, TG, and HDL-C in the PCOS rats. Rha treatment also modulated the serum levels of sex hormones, which decreased T, E2, and LH and increased FSH in PCOS rats. In addition, Rha treatment modulated insulin resistance and increased gene expression of antioxidant enzymes (Cat, Sod2, Gpx3, Mgst1, Prdx3, Gsta4, Gsr, and Sod1) in the ovaries of the PCOS rats. Finally, Rha treatment appeared to increase the activity of PPAR-γ and inhibit the TGF-β1/Smad pathway in the ovaries of the PCOS rats. Our findings suggest that Rha significantly ameliorated metabolic disturbances and ovarian fibrosis in the PCOS rats. Rha perhaps is an effective compound for preventing ovarian fibrosis in the future.

Funder

Ministry of Human Resources and Social Security

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

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