Synthesis, Isolation and Characterization of Process-Related Impurities in Salbutamol Sulphate-Reference-Cited by-同舟云学术

Synthesis, Isolation and Characterization of Process-Related Impurities in Salbutamol Sulphate

Published:2011 Issue:4 Volume:8 Page:1720-1727
ISSN:0973-4945
Container-title:E-Journal of Chemistry
language:en
Short-container-title:E-Journal of Chemistry

Author:

Sharma Yogesh Kumar¹,Agarwal Dau Dayal²,Bhure Sudesh²,Mukharjee Rajendra Nath²,Sahu Pramod Kumar²,Bhardwaj Santosh²

Affiliation:

1. Department of Industrial Chemistry, Jiwaji University, Gwalior-475011, Madhya Pradesh, India

2. Pharmasolve Specialities (I) Pvt. Ltd. Mumbai, India

Abstract

Three known and one unknown impurities in salbutamol sulphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the known and unknown imputities.

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2011/230231.pdf

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