A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach-Reference-Cited by-同舟云学术

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

Published:2019-01-16 Issue: Volume:2019 Page:1-9
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Sauer André C.¹,Wolf Lucas¹,Quoos Natália¹,Rodrigues Mariele B.¹,Braga Antônio L.²^ORCID,Rodrigues Oscar E. D.¹,Dornelles Luciano¹^ORCID

Affiliation:

1. Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil

2. Departamento de Química, Universidade Federal de Santa Catarina, P.O Box 476, 88040-900 Florianópolis, SC, Brazil

Abstract

A straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approach gives the desired products using acetone/water as solvent in very short reaction times.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2019/8589325.pdf

Reference50 articles.

1. Synthesis of non-symmetrically substituted 1,2,4-oxadiazole derived liquid crystals

2. Synthesis of new bipolar host materials based on 1,2,4-oxadiazole for blue phosphorescent OLEDs

3. Synthesis, insecticidal activity, and structure–activity relationship (SAR) of anthranilic diamides analogs containing oxadiazole rings