Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis

Author:

Bae Kil-Joon1ORCID,Jeong Ji-Won1,Choi Chan-Hun2,Won Jeong-Yoon3,Kim Tae-Gwang4ORCID,Kim Young-Ran5,Na Chang-Su2ORCID,Kim Seon-Jong1ORCID

Affiliation:

1. Department of Korean Medical Rehabilitation, Mokpo Korean Medicine Hospital of Dongshin University, 313 Baengnyeon-daero, Mokpo-si 58665, Republic of Korea

2. College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea

3. Department of Korean Medical Rehabilitation, Dongshin Korean Medicine Hospital, 351 Omok-ro, Yangcheon-gu, Seoul 07999, Republic of Korea

4. Department of Korean Medical Rehabilitation, Gwangju Korean Medicine Hospital of Dongshin University, 141, Wolsan-ro, Nam-gu, Gwangju 61619, Republic of Korea

5. College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea

Abstract

Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis. ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine. This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis. Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group. Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed. Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured. ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity. Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels. This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model. These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis. However, further studies are required to elucidate the corresponding mechanisms.

Funder

Ministry of Health and Welfare

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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