The Influence of Interleukin17AandIL17FPolymorphisms on Chronic Periodontitis Disease in Brazilian Patients

Abstract

A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin17A (IL17A)G197A (rs2275913) andIL17FT7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher’s exact tests, odds ratios (OR), and 95% confidence intervals (CIs). SNPStas software was used to calculate Hardy-Weinberg equilibrium.IL17AAA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models (P=0.09; OR = 2.53 andP=0.03; OR = 2.46, resp.), the females with CP (P=0.01, OR = 4.34), Caucasoid patients with CP (P=0.01, OR = 3.45), and nonsmoking Caucasian patients with CP (P=0.04, OR = 3.51). TheIL17AA allele was also more frequent in Caucasians with CP (P=0.04, OR = 1.59).IL17FT7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil, theIL17Ars2275913 polymorphisms,IL17AAA genotype, and the A allele were associated with a susceptibility to chronic periodontitis.