Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity-Reference-Cited by-同舟云学术

Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

Published:2022-04-16 Issue: Volume:2022 Page:1-12
ISSN:2090-2158
Container-title:International Journal of Nephrology
language:en
Short-container-title:International Journal of Nephrology

Author:

Ayza Muluken Altaye¹^ORCID,Zewdie Kaleab Alemayehu²^ORCID,Yigzaw Elias Fitsum³,Ayele Solomon Gashaw⁴,Tesfaye Bekalu Amare²^ORCID,Tafere Gebrehiwot Gebremedhin²^ORCID,Abrha Muzey Gebreyohannes⁵^ORCID

Affiliation:

1. Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia

2. Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia

3. Clinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

4. Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

5. Department of Medicinal Chemistry, School of Pharmacy, Mekelle University, Mekelle, Ethiopia

Abstract

Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.

Publisher

Hindawi Limited

Subject

Nephrology

Link

http://downloads.hindawi.com/journals/ijn/2022/5096825.pdf

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