Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

Author:

Herrero-Martin David1,Fourtouna Argyro1,Niedan Stephan1,Riedmann Lucia T.1,Schwentner Raphaela1ORCID,Aryee Dave N. T.1

Affiliation:

1. Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria

Abstract

Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.

Publisher

Hindawi Limited

Subject

Radiology Nuclear Medicine and imaging,Oncology

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