Heterogeneous Catalysts in Pictet-Spengler-Type Reactions-Reference-Cited by-同舟云学术

Heterogeneous Catalysts in Pictet-Spengler-Type Reactions

Published:2013 Issue: Volume:2013 Page:1-5
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Quevedo Rodolfo¹,Perdomo Camilo²,Moreno Sonia²

Affiliation:

1. Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, 45-03 Carrera 30, Bogotá 4-72, Colombia

2. Estado Solido y Catálisis Ambiental (ESCA), Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, 45-03 Carrera 30, Bogotá 4-72, Colombia

Abstract

Several solid catalysts were evaluated as an alternative for 1,2,3,4-tetrahydroisoquinoline synthesis by means of the Pictet-Spengler reaction. The reaction catalysed by a mixed oxide (Mg and Al) led to the best yield and good regioselectivity; using an Al-pillared bentonite led to good yields and total regioselectivity. The results revealed no direct relationship between catalyst acidity and yield.

Funder

Universidad Nacional de Colombia

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2013/125302.pdf

Reference24 articles.

1. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics

2. Synthesis and Molecular Modeling of 1-Phenyl-1,2,3,4-tetrahydroisoquinolines and Related 5,6,8,9-Tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 Dopamine Antagonists

3. Synthesis and Antimuscarinic Properties of Quinuclidin-3-yl 1,2,3,4-Tetrahydroisoquinoline-2-carboxylate Derivatives as Novel Muscarinic Receptor Antagonists