Evaluation of Task-Related Brain Activity: Is There a Role for 18F FDG-PET Imaging?-Reference-Cited by-同舟云学术

Evaluation of Task-Related Brain Activity: Is There a Role for 18F FDG-PET Imaging?

Published:2019-07-02 Issue: Volume:2019 Page:1-10
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Chiaravalloti Agostino¹²^ORCID,Micarelli Alessandro³^ORCID,Ricci Maria⁴,Pagani Marco⁵,Ciccariello Gabriele²,Bruno Ernesto³,Alessandrini Marco³^ORCID,Schillaci Orazio¹²

Affiliation:

1. Department of Biomedicine and Prevention, Faculty of Medicine and Surgery, Tor Vergata University, Rome, Italy

2. IRCCS Neuromed, UOC Medicina Nucleare, Pozzilli (IS), Italy

3. Department of Clinical Sciences and Translational Medicine, Faculty of Medicine and Surgery, Tor Vergata University, Rome, Italy

4. Department of Radiological, Oncological and Pathological Sciences, Faculty of Medicine and Surgery, La Sapienza University, Rome, Italy

5. Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy

Abstract

Positron emission tomography (PET) with 2-[18F]-fluorodeoxyglucose (FDG) has been widely used for the evaluation of cortical glucose metabolism in several neurodegenerative disorders while its potential role in the evaluation of cortical and subcortical activity during a task in the healthy and pathological brain still remains to be a matter of debate. Few studies have been carried out in order to investigate the potential role of this radiotracer for the evaluation of brain glucose consumption during dynamic brain activation. The aim of this review is to provide a general overview of the applications of FDG-PET in the evaluation of cortical activation at rest and during tasks, describing first the physiological basis of FDG distribution in brain and its kinetic in vivo. An overview of the imaging protocols and image interpretation will be provided as well. As a last aspect, the results of the main studies in this field will be summarized and the results of PET findings performed in healthy subjects and patients suffering from various diseases will be reported.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2019/4762404.pdf

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