Detailed Distribution of Corneal Epithelial Thickness and Correlated Characteristics Measured with SD-OCT in Myopic Eyes

Abstract

Purpose.To investigate the detailed distribution of corneal epithelial thickness in single sectors and its correlated characteristics in myopic eyes.Methods.SD-OCT was used to measure the corneal epithelial thickness distribution profile. Differences of corneal epithelial thickness between different parameters and some correlations of characteristics were calculated.Results.The thickest and thinnest part of epithelium were found at the nasal-inferior sector (P<0.05) and at the superior side (P<0.05), respectively. Subjects in the low and moderate myopia groups have thicker epithelial thickness than those in the high myopia group (P<0.05). Epithelial thickness was 1.39 μm thicker in male subjects than in female subjects (P<0.001). There was a slight negative correlation between corneal epithelial thickness and age (r=−0.13,P=0.042). Weak positive correlations were found between corneal epithelial thickness and corneal thickness (r=0.148,P=0.031). No correlations were found between corneal epithelial thickness, astigmatism axis, corneal front curvature, and IOP.Conclusions.The epithelial thickness is not evenly distributed across the cornea. The thickest location of the corneal epithelium is at the nasal-inferior sector. People with high myopia tend to have thinner corneal epithelium than low–moderate myopic patients. The corneal epithelial thickness is likely to be affected by some parameters, such as age, gender, and corneal thickness.