Connexins and Diabetes-Reference-Cited by-同舟云学术

Connexins and Diabetes

Published:2012 Issue: Volume:2012 Page:1-8
ISSN:2090-8016
Container-title:Cardiology Research and Practice
language:en
Short-container-title:Cardiology Research and Practice

Author:

Wright Josephine A.¹^ORCID,Richards Toby¹^ORCID,Becker David L.¹

Affiliation:

1. Department of Vascular Surgery and Department of Cell and Developmental Biology, University College London Hospital, 74 Huntley Street, London NW1 2BU, UK

Abstract

Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called “connexins.” In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms of connexin influence and the role of individual connexins in various tissues and how these are affected in diabetes. Connexins may be a future target by both genetic and pharmacological approaches to develop treatments for the treatment of diabetes and its complications.

Publisher

Hindawi Limited

Subject

Cardiology and Cardiovascular Medicine

Link

http://downloads.hindawi.com/journals/crp/2012/496904.pdf

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