Probable Change of Sleep Parameters after Resection and Reconstruction Surgeries in Patients with Oral Cavity or Oropharyngeal Cancers

Author:

Huang Ethan I.123ORCID,Huang Shu-Yi245,Lin Yu-Ching2346,Lin Chieh-Mo47,Lin Chin-Kuo47,Yeh Hsuan-Keng8,Wu Chao-Min8

Affiliation:

1. Department of Otolaryngology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

2. Sleep Center of Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

3. School of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

4. Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

5. Department of Nursing, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan

6. Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan

7. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

8. Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan

Abstract

In patients of oral cavity or oropharyngeal cancers, resection of the tumor and reconstruction of the defect may reduce the framework, add a bulky flap, alter the tissue flexibility, and contribute to postoperative obstructive sleep apnea (OSA). Postoperative OSA and the potential consequences may decrease the survival rate and reduce patients’ quality of life. It is unclear whether the surgery is associated with postoperative OSA. Here, we compared the polysomnographies (PSGs) before and after the surgery in 15 patients of oral cavity or oropharyngeal cancers (out of 68 patients of head and neck cancers) without a chemo- or radio-therapy. Each patient received the second PSG before the start of any indicated adjuvant therapy to prevent its interference. There were 14 men and 1 woman, with a mean age and a standard deviation (SD, same in the following) of 56.2 ± 12.8 years. There were 6 tongue cancers, 5 buccal cancers, 2 tonsil cancer, 1 lower gum cancer, and 1 trigone cancer. The results show that the surgery changed sleep parameters insignificantly in apnea-hypopnea index (AHI), mean oxyhemoglobin saturation of pulse oximetry (SpO2), minimum SpO2, mean desaturation, and desaturation index but increased mean heart rate in the patients with free flaps. These results hint that the effect of surgery on developing OSA was small in this sample, with a longer plate or a larger framework for a bulkier free flap. It needs future studies with a large sample size to generalize this first observation.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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