C-Reactive Protein +1444C/T Polymorphism Is Associated with the Susceptibility to Pulmonary Tuberculosis

Abstract

Objective. The T allele of C-reactive protein (CRP) +1444C/T (rs1130864) polymorphism was associated with increased risk for some inflammatory conditions. The objective of the study was to explore the association between the CRP +1444C/T polymorphism with the susceptibility to pulmonary tuberculosis (PTB) in a Chinese population. Methods. This case-control study enrolled 480 PTB patients and 480 healthy controls. The CRP +1444C/T polymorphism was determined using Sanger sequencing. The odds ratio (OR) and 95% confidence interval (CI) were assessed to examine the strength of genetic correlation. Results. The genotype and allele frequencies of PTB patients differed from controls (CT vs. CC, $\text{OR}=1.924$ , 95% CI: 1.099-3.371, $\text{adjusted}P\text{value}=0.022$ ; T vs. C, $\text{OR}=1.884$ , 95% CI: 1.085-3.273, $\text{adjusted}P\text{value}=0.024$ ). Stratified analysis by sex found that PTB patients’ genotype and allele frequencies differed from controls in the male subgroup but not the female subgroup. Conclusion. In conclusion, the minor T allele of CRP +1444C/T polymorphism was associated with increased PTB risk.