The Effects of Curcumin on Wound Healing in a Rat Model of Nasal Mucosal Trauma

Author:

Emiroglu Gokhan1ORCID,Ozergin Coskun Zerrin1ORCID,Kalkan Yildiray2,Celebi Erdivanli Ozlem1,Tumkaya Levent2ORCID,Terzi Suat1ORCID,Özgür Abdulkadir1ORCID,Demirci Munir1ORCID,Dursun Engin1

Affiliation:

1. Department of Otorhinolaryngology, Recep Tayyip Erdogan University Medical Faculty, Rize, Turkey

2. Department of Histology and Embryology, Recep Tayyip Erdogan University Medical Faculty, Rize, Turkey

Abstract

We explored the effects of topical curcumin on the healing of nasal mucosal wounds. A total of 32 Sprague-Dawley Albino rats were randomized in equal numbers into four groups, and unilateral nasal wounds were created using an interdental brush. Group 1 (the sham-control group) contained untreated rats with traumatized right-side nasal cavities; Group 2 and 3 rats were similarly traumatized and treated with topical curcumin (5 and 10 mg/mL) dissolved in dimethyl sulfoxide daily for 7 days after trauma; Group 4 rats were treated with topical dimethyl sulfoxide only. All rats were decapitated on day 15 and the healing sites evaluated by blinded observers in terms of the presence of cellular hyperplasia, goblet cell hypertrophy and degeneration, leucocytic infiltration, ciliary loss and degeneration, edema, and vascular dilation. On histopathological evaluation, all of cellular hyperplasia, leukocytic infiltration, and edema were significantly reduced in Group 3 compared with Group 1 (p=0.001, p=0.004, and p=0.008, resp.). Thus, curcumin reduced the inflammatory response and significantly accelerated wound healing.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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