ceRNAs in Cancer: Mechanism and Functions in a Comprehensive Regulatory Network

Author:

Yang Ni1ORCID,Liu Kuo1ORCID,Yang Mengxuan1ORCID,Gao Xiang1ORCID

Affiliation:

1. Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

Abstract

Noncoding RNAs have been shown with powerful ability in post-transcriptional regulation, enabling intertwined RNA crosstalk and global molecular interaction in a large amount of dysfunctional conditions including cancer. Competing endogenous RNAs (ceRNAs) are those competitively binding with shared microRNAs (miRNAs), freeing their counterparts from miRNA-induced degradation, thus actively influencing and connecting with each other. Constantly updated analytical approaches boost outstanding advancement achieved in this burgeoning hotspot in multilayered intracellular communication, providing new insights into pathogenesis and clinical treatment. Here, we summarize the mechanisms and correlated factors under this RNA interplay and deregulated transcription profile in neoplasm and tumor progression, underscoring the great significance of ceRNAs for diagnostic values, monitoring biomarkers, and prognosis evaluation in cancer.

Publisher

Hindawi Limited

Subject

Oncology

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