Patients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responses

Abstract

Background.Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory event-related delta oscillations of MCI subjects.Method.The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age- and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded fromF3, Fz,F4,C3,Cz,C4,P3, Pz,P4,O1, Oz, andO2locations. The maximum peak-to-peak amplitudes for each subject’s averaged delta response (0.5–2.2 Hz) were measured.Results.The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect forgroups(F(1.41)= 4.84,P=0.033), indicating a larger delta response for healthy controls than MCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sitesF3, Fz,F4,Cz,C4, and Pz.Discussion.Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.