Assessment of theE-Selectinrs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Author:

Sandoval-Pinto Elena12,Ramon Padilla-Gutiérrez Jorge2,Valdes-Alvarado Emmanuel12,Janet García-González Ilian23,Valdez-Haro Angelica23,Francisco Muñoz-Valle Jose2,Enrique Flores-Salinas Hector4,Rivas Fernando5,Valle Yeminia2

Affiliation:

1. Centro Universitario de Ciencias de la Salud, UdeG. Sierra Mojada 950, 44340 Guadalajara, JAL, Mexico

2. Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44340 Guadalajara, JAL, Mexico

3. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Edificio Q, Primer Piso, Colonia Independencia, 44340 Guadalajara, JAL, Mexico

4. IMSS, Centro Médico Nacional de Occidente, Belisario Dominguez 1000, Colonia Independencia, 44340 Guadalajara, JAL, Mexico

5. Hospital General de Occidente, Secretaria de Salud Jalisco, Avenida Zoquipan 1050, Colonia Zoquipan, 45170 Zapopan, JAL, Mexico

Abstract

Introduction. The acute coronary syndrome (ACS) is a complex disease where genetic and environmental factors are involved.E-selectingene is a candidate for ACS progression due to its contribution in the inflammatory process and endothelial function. The rs5361 (561A>C) polymorphism in theE-selectingene has been linked to changes in gene expression, affinity for its receptor, and plasmatic levels; therefore it is associated with an increased risk of cardiovascular disease. The aim of this study was to determine the association of the rs5361 polymorphism with ACS and to measure serum levels of soluble E-selectin (sE-selectin).Materials and Methods. 283 ACS patients and 205 healthy subjects (HS) from Western Mexico were included. The polymerase chain reaction-restriction fragment length polymorphism was used to determine the rs5361 polymorphism. The sE-selectin levels were measured by enzyme-linked immunosorbent assay.Results. Neither genotype nor allele frequencies of the rs5361 polymorphism showed statistical differences between groups. The sE-selectin levels were significantly higher in ACS patients compared to HS (54.58 versus 40.41 ng/ml,P=0.02). The C allele had no effect on sE-selectin levels.Conclusions. The rs5361E-selectingene polymorphism is not a susceptibility marker for ACS in Western Mexico population. However, sE-selectin may be a biological marker of ACS.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Reference78 articles.

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