Correlation between Serum Oxidative Stress Level and Serum Uric Acid and Prognosis in Patients with Hepatitis B-Related Liver Cancer before Operation

Author:

Yu Maowen1,Zhang Chaozhu2,Tang Hongbo1,Xiao Chaohui3ORCID

Affiliation:

1. Department of Clinical Lab, Jintang Hospital, West China Hospital, Sichuan University Jintang First People’s Hospital, Chengdu 610400, China

2. Gastroenterology Department, Chinese PLA Army 951 Hospital, Kuerle 841000, China

3. Department of Hepatobiliary Surgery, Fifth Medical Centre of Chinese PLA General Hospital, Beijing 100039, China

Abstract

Aiming to explore the correlation between preoperative serum oxidative stress level and serum uric acid and prognosis of hepatitis B-related liver cancer, the clinical data of 712 patients with hepatitis B-related liver cancer from January 2019 to December 2020 were retrospectively analyzed. By using the receiver operating curve, the optimal critical values of preoperative superoxide dismutase (SOD), malondialdehyde (MDA), and serum uric acid (SUA) are determined. The single-factor and multifactor Cox models are applied to screen out the suspicious factors affecting the prognosis of patients with hepatitis B-related liver cancer. According to the survival status of patients, the optimal thresholds of SOD, MDA, and SUA before operation were 58.055/mL, 10.825 nmol/L, and 312.77 nmol/L, respectively. The results of univariate analysis show that the prognosis of patients is significantly correlated with preoperative SOD, MDA, and SUA levels and TNM staging P < 0.05 . Additionally, multivariate analysis demonstrates that preoperative SOD < 58.055 U/mL and SUA ≥ 312.770 mmol/L and TNM stage III-IV are independent risk factors for postoperative prognosis P < 0.05 . Our study suggests that SOD, SUA, and TNM staging have certain value in judging the early prognosis of patients with hepatitis B-related liver cancer. Patients with high preoperative SOD level and low preoperative SUA level can obtain better prognosis.

Publisher

Hindawi Limited

Subject

Health Informatics,Biomedical Engineering,Surgery,Biotechnology

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