The -938C>A Polymorphism inMYD88Is Associated with Susceptibility to Tuberculosis: A Pilot Study-Reference-Cited by-同舟云学术

The -938C>A Polymorphism inMYD88Is Associated with Susceptibility to Tuberculosis: A Pilot Study

Published:2016 Issue: Volume:2016 Page:1-5
ISSN:0278-0240
Container-title:Disease Markers
language:en
Short-container-title:Disease Markers

Author:

Aggelou Kalliopi¹²,Siapati Elena Konstantina²,Gerogianni Irini¹,Daniil Zoe¹,Gourgoulianis Konstantinos¹,Ntanos Ioannis²,Simantirakis Emmanouel³,Zintzaras Elias⁴,Mollaki Vassiliki⁵⁶,Vassilopoulos George³⁷^ORCID

Affiliation:

1. Department of Respiratory Medicine, University of Thessaly Medical School, Larissa, Greece

2. 9th Department for Chest Diseases, “Sotiria” Hospital, Athens, Greece

3. Cell and Gene Therapy Laboratory, Center for Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

4. Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece

5. Hellenic National Bioethics Committee, Athens, Greece

6. Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological Educational Institution of Athens, Athens, Greece

7. Division of Haematology, University of Thessaly Medical School, Larissa, Greece

Abstract

Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB.Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB.Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for theMYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms.Results. TheMYD88-938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89–11.28,p=0.01).Conclusions. TheMYD88-938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/dm/2016/4961086.pdf

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