RANKL Expression in Periodontal Disease: Where Does RANKL Come from?-Reference-Cited by-同舟云学术

RANKL Expression in Periodontal Disease: Where Does RANKL Come from?

Published:2014 Issue: Volume:2014 Page:1-7
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Chen Bin¹^ORCID,Wu Wenlei¹,Sun Weibin¹,Zhang Qian¹^ORCID,Yan Fuhua¹^ORCID,Xiao Yin²^ORCID

Affiliation:

1. Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China

2. Bone Research Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, Qld 4059, Australia

Abstract

Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.

Funder

Nanjing Health Bureau

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2014/731039.pdf

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