Enhancement of Neocortical-Medial Temporal EEG Correlations during Non-REM Sleep

Author:

Axmacher Nikolai12,Helmstaedter Christoph1,Elger Christian E.12,Fell Juergen1

Affiliation:

1. Department of Epileptology, University of Bonn, 53105 Bonn, Germany

2. Life and Brain Academic Research, University of Bonn, 53105 Bonn, Germany

Abstract

Interregional interactions of oscillatory activity are crucial for the integrated processing of multiple brain regions. However, while the EEG in virtually all brain structures passes through substantial modifications during sleep, it is still an open question whether interactions between neocortical and medial temporal EEG oscillations also depend on the state of alertness. Several previous studies in animals and humans suggest that hippocampal-neocortical interactions crucially depend on the state of alertness (i.e., waking state or sleep). Here, we analyzed scalp and intracranial EEG recordings during sleep and waking state in epilepsy patients undergoing presurgical evaluation. We found that the amplitudes of oscillations within the medial temporal lobe and the neocortex were more closely correlated during sleep, in particular during non-REM sleep, than during waking state. Possibly, the encoding of novel sensory inputs, which mainly occurs during waking state, requires that medial temporal dynamics are rather independent from neocortical dynamics, while the consolidation of memories during sleep may demand closer interactions between MTL and neocortex.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Hindawi Limited

Subject

Neurology (clinical),Neurology

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