Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl]-Reference-Cited by-同舟云学术

Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl]

Published:2010 Issue: Volume:2010 Page:1-11
ISSN:1565-3633
Container-title:Bioinorganic Chemistry and Applications
language:en
Short-container-title:Bioinorganic Chemistry and Applications

Author:

Elsayed Shadia A.¹,El-Hendawy Ahmed M.²,Mostafa Sahar I.³^ORCID,Jean-Claude Bertrand J.⁴,Todorova Margarita⁴,Butler Ian S.¹

Affiliation:

1. Department of Chemistry, McGill University, Montreal, QC, H3A 2K6, Canada

2. Chemistry Department, Faculty of Science, Mansoura University, Damietta 34517, Egypt

3. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

4. Department of Medicine, Royal Victoria Hospital, Montreal, QC, H3A 1A1, Canada

Abstract

New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (H1,C13, andP31), and electronic spectral data. The X-ray crystal structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Organic Chemistry,Biochemistry

Link

http://downloads.hindawi.com/journals/bca/2010/149149.pdf

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