Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection-Reference-Cited by-同舟云学术

Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection

Published:2016 Issue: Volume:2016 Page:1-8
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Bikbova Guzel¹^ORCID,Oshitari Toshiyuki¹^ORCID,Baba Takayuki¹^ORCID,Yamamoto Shuichi¹

Affiliation:

1. Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670, Japan

Abstract

Diabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregularity. This review presents recent findings on impaired corneal innervation in diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy. Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic keratopathy are presented.

Funder

Ministry of Education, Science, Sports and Culture of the Japanese Government

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2016/5140823.pdf

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