Association of Serum PSP/REG Iαwith Renal Function in Type 2 Diabetes Mellitus

Abstract

Purpose. Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iαlevels may reflect renal dysfunction. The purpose of this study was to detect the relationship between PSP/REG Iαand renal function in subjects with and without type 2 diabetes mellitus (T2DM).Methods. This cross-sectional study was conducted at Zhongda Hospital, affiliated with Southeast University in China. Serum PSP/REG Iαlevels were measured using a method of enzyme-linked immunosorbent assay. Baseline characteristics and biochemical parameters, such as blood urea nitrogen (BUN), serum creatinine (SCr), and uric acid (UA), were collected. The estimated glomerular filtration rate (eGFR) of each individual was calculated using the diagnostic criteria for renal function. Correlations between PSP/REG Iαand renal function parameters were analyzed by Spearman’s rank correlation coefficient using SPSS 20.0 software.Results. Serum PSP/REG Iαlevels were significantly higher in T2DM patients than those without T2DM (P<0.05). The level of PSP/REG Iαwas positively correlated with age, SCr, and BUN and negatively correlated with eGFR. The ordinal multiple logistic regression analysis further illustrated that PSP/REG Iαlevels were negatively related with eGFR in both groups after adjusting for other parameters.Conclusions. Serum PSP/REG Iαlevel is significantly upregulated in T2DM patients and reflects renal function in both T2DM and nondiabetic control groups. The relationship between PSP/REG Iαand eGFR suggested that PSP/REG Iαmight be a potential indicator of renal dysfunction.