The Drop That Spilled the Cup: Acute Myocardial Infarction in a Young Woman with Underlying Thrombophilic Polymorphisms and Oral Contraceptive Use

Author:

Russo Nunzio12ORCID,Franzì Enrico13ORCID,Capilli Gianfranco14,Patané Anella Antonietta1,Russo Silvia Paola5ORCID,Evola Rosario1ORCID

Affiliation:

1. Unit of Cardiovascular Disease, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy

2. Cardiac Intensive Care Unit, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy

3. Cardiovascular Imaging, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy

4. Cardiac Catheterization Lab, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy

5. Vita-Salute San Raffaele University, San Raffaele Hospital, 58 Via Olgettina, 20132 Milan, Italy

Abstract

We present the case of a 28-year-old woman who was admitted to our cardiology unit for acute coronary syndrome. Her history was notable for cardiovascular disease familiarity, active smoking, and oral contraceptive use. On further analysis, she was noted to have thrombophilic polymorphisms involving the plasminogen activator inhibitor (PAI), angiotensin-converting enzyme (ACE), and methylenetetrahydrofolate reductase (MTHFR) genes. We discuss the implications that these cofactors may have had in the genesis of the disease.

Publisher

Hindawi Limited

Subject

Cardiology and Cardiovascular Medicine

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