Anti-dsDNA Is Associated with Favorable Prognosis in Myasthenia Gravis: A Retrospective Study

Abstract

Objectives. To investigate the presence of serum antinuclear antibody (ANA) and anti-double-stranded DNA antibody (anti-dsDNA) in patients with myasthenia gravis (MG) and analyze the clinical characteristics and prognostic factors associated with MG. Methods. We retrospectively enrolled 363 patients with MG and analyzed the clinical characteristics and follow-up data between patients positive and negative for ANA and anti-dsDNA. We defined a Myasthenia Gravis Activities of Daily Living (MG-ADL) reduction as a main prognosis predictor and used logistic regression to determine independent factors associated with prognosis. We built a nomogram to predict prognosis and evaluate the internal validity of the model. Results. Ninety-eight (27.0%) patients were positive for ANA, and 51 (14.0%) were positive for anti-dsDNA. Patients positive for ANA and anti-dsDNA antibodies tended to be female and positive for acetylcholine receptor antibody (AChR-Ab). The rate of thymoma was higher in anti-dsDNA-positive patients with MG (p-dsDNA-MG) than in patients negative for anti-dsDNA (49.0% vs. 26.0%, $p=0.001$ ), and p-dsDNA-MG was associated with reduced MG-ADL score. Regression analysis showed that except for age of onset ( $\text{OR}=0.986$ , $95\%\text{CI}=0.973–0.999$ , $p=0.037$ ), anti-dsDNA ( $\text{OR}=2.800$ , $95\%\text{CI}=1.381–5.679$ , $p=0.004$ ), ptosis ( $\text{OR}=2.930$ , $95\%\text{CI}=1.827–4.699$ , $p<0.001$ ), and eye movement disorder ( $\text{OR}=2.815$ , $95\%\text{CI}=1.672–4.741$ , $p<0.001$ ) were independent predictive factors of a favorable prognosis of MG. These predictors were used to generate a nomogram with an excellent predictive value. Conclusions. Being female and the presence of AChR-Ab were features of ANA- or anti-dsDNA-positive MG. The presence of anti-dsDNA was associated with a favorable prognosis of MG.