Biocompatible Silver Nanoparticle-Modified Natural Diatomite with Anti-Infective Property

Author:

Sun Haolin12ORCID,Wen Xiaoxiao3ORCID,Zhang Xiang3ORCID,Wei Donglei3ORCID,Yang Huilin23ORCID,Li Chunde1ORCID,Yang Lei23ORCID

Affiliation:

1. Department of Orthopedic, Peking University First Hospital, Beijing 100034, China

2. International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou 215006, China

3. Institute of Orthopaedics and Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou 215006, China

Abstract

Nanosilver as an alternative antibacterial agent of antibiotics has been researched for possible applications in various orthopedic implants. However, it is imperative to achieve controllable release of Ag+ to reduce its cytotoxic effect on normal tissue. Here, a nanosilver release system that has potential to be used in anti-infective bone cement was reported. Nanosilver modified diatomite was developed through the reaction of Tollens’ reagent to improve the antibacterial effect and natural diatomite was used as the carrier of Ag+ ions for controlled release. Cytotoxicity and the antibacterial activities of the nanosilver release system were characterized. After 3 days, the NIH3T3 cells cultured in the extract of nanosilver modified diatomite with an initial concentration of 0.5 mg/ml showed better cell viability than cells cultured in α-MEM. The density of MC3T3-E1 cells cultured in the extract of nanosilver modified diatomite at the same concentration did not differ significantly from the density of cells cultured in α-MEM. The nanosilver modified diatomite exhibited antibacterial effect against E. coli and S. aureus when the concentration was higher than 0.5 mg/ml. With appropriate selection of Ag+ concentration, the nanosilver modified diatomite is promising for improving the antibacterial effect while not affecting the biocompatibility of reinforced calcium phosphate bone cement.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Materials Science

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