New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells

Author:

Lin Lixian1ORCID,Tang Zengqi1ORCID,Shi Zhenrui1ORCID,Guo Qing1ORCID,Xiong Hui1ORCID

Affiliation:

1. Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China

Abstract

Artesunate, one of the derivatives of artemisinin (“qinghaosu” in Chinese), is known as an antimalarial drug with high efficiency and low toxicity. Of interest, emerging evidences suggest that artesunate also possesses an immunomodulatory effect during innate and adaptive immune responses in cell types and context-dependent manner. Although it shows promising application in many diseases, such as inflammatory diseases, hypersensitivity, autoimmune diseases, and cancers, little is known about underlying molecular. In this review, we summarize recent advances of how artesunate regulates innate and adaptive immune cells. In addition, its potential application in immune-related diseases is also highlighted.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Reference58 articles.

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