Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential

Author:

Ni Lihua1ORCID,Yuan Cheng2ORCID,Wu Xiaoyan1ORCID

Affiliation:

1. Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

2. Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Abstract

Recent progress has been made in understanding the roles and mechanisms of endoplasmic reticulum (ER) stress in the development and pathogenesis of diabetic nephropathy (DN). Hyperglycemia induces ER stress and apoptosis in renal cells. The induction of ER stress can be cytoprotective or cytotoxic. Experimental treatment of animals with ER stress inhibitors alleviated renal damage. Considering these findings, the normalization of ER stress by pharmacological agents is a promising approach to prevent or arrest DN progression. The current article reviews the mechanisms, roles, and therapeutic aspects of these findings.

Funder

Wuhan University

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

Reference106 articles.

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