Affiliation:
1. Department of Chemistry, Kafkas University, 36100 Kars, Turkey
Abstract
In this study, thirteen novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR,1H NMR,13C NMR and UV spectral data. The synthesized compounds were analyzed for theirin vitropotential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT andα-tocopherol. The data reveal that the compounds demonstrate a marked capacity for iron binding, especially5aand7cIn addition to this, the compounds4were titrated potentiometrically with TBAH in non-aqueous solvents because of the weak acidic properties of 4,5-dihydro-1H-1,2,4-triazol-5-one ring N-H group.
Funder
Turkish Scientific and Technological Council
Cited by
12 articles.
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1. Synthesis, Biological and Acidic Properties of Some New 2-Ethoxy-4-[(3-alkyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethine]-phenyl 2-Methylbenzoate Derivatives;Moscow University Chemistry Bulletin;2022-12
2. Investigation of acidic properties of 2-ethoxy-6-(3-substitue-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl-azomethine)-phenyl benzoates;Turkish Journal of Analytical Chemistry;2021-11-11
3. New ternary palladium(II) complexes: Synthesis, characterization, in vitro anticancer and antioxidant activities;Inorganic Chemistry Communications;2019-07
4. In vitro and histological investigation of antitumor effect of some triazole compounds in colon cancer cell line;Journal of Cellular Biochemistry;2019-02-15
5. Theoretical and spectroscopic (FT-IR, NMR and UV–Vis.) characterizations of 3-p-chlorobenzyl-4-(4-carboxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-one molecule;Journal of Molecular Structure;2017-01