Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population

Abstract

It has been suggested that genetic factors contribute to patients’ vulnerability to breast cancer (BC). The programmed cell death 6 interacting protein (PDCD6IP) encodes for a protein that is known to bind to the products of the PDCD6 gene, which is involved in the apoptosis pathway. The aim of this case-control study is to investigate the relationship between thePDCD6IP15 bp insertion/deletion (I/D) polymorphism (rs28381975) and BC risk in an Iranian population. A total of 491 females, including 266 BC patients and 225 control subjects without cancer, were enrolled into the study. Our findings revealed that thePDCD6IP15 bp I/D polymorphism decreased the risk of BC in codominant (OR=0.44, 95%CI=0.31–0.65,p<0.0001, I/D versus DD;OR=0.39, 95%CI=0.17–0.88,p=0.030, I/I versus DD) and dominant (OR=0.44, 95%CI=0.30–0.63,p<0.0001, D/I + I/I versus D/D) tested inheritance models. Also, thePDCD6IPI allele significantly decreased the risk of BC (OR=0.59, 95%CI=0.45–0.78,p<0.001) compared to the D allele.