Clinical Use of the Low-Molecular-Weight Heparins in Cancer Patients: Focus on the Improved Patient Outcomes

Author:

Chao Bo H.12,Lepeak Lisa12,Leal Ticiana12,Robins H. Ian123

Affiliation:

1. Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison WI 53792, USA

2. University of Wisconsin Paul Carbone Comprehensive Cancer Center, 600 Highland Avenue, Madison, WI 53792, USA

3. Departments of Medicine, Human Oncology, and Neurology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA

Abstract

Patients with malignant neoplastic diseases represent a high-risk population relative to thromboembolic disease. With the advent of improved and accessible diagnostic technology, for example, ultrasound and/or spiral CT scans, timely diagnosis of venous thromboembolic events (VTE) is readily accomplished. The introduction of low-molecular-weight heparin (LMWH) approximately two decades ago (in contrast to unfractionated heparin and vitamin K antagonists) has provided a class of agents with a favorable therapeutic index. In the review to follow, the literature regarding the use of LMWH in oncologic patient populations is summarized. Topics addressed include prophylaxis, and treatment as well as consideration of the potential anti-neoplastic properties of this class of drugs.

Funder

Kathleen Reader Memorial Research Fund

Publisher

Hindawi Limited

Subject

Cardiology and Cardiovascular Medicine,Hematology

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