Affiliation:
1. Department of Biological Engineering, Inha University, Incheon 402-751, Republic of Korea
Abstract
Skin regeneration is a complex process involving massive proliferation and alignment of cells, where there are obstacles to completion of regeneration, the main one being excessive generation of reactive oxygen species (ROS) from inflammation or infection.Spirulina, blue-green algae that has antioxidant and anti-inflammatory activities, has been used to relieve such ROS stress. In this study,Spirulinaextract loaded PCL (Spirulina-PCL) nanofiber was evaluated as a cutaneous wound dressing in view of antioxidative mechanism. In addition to increasing fibroblast viability, theSpirulinaextract and its dressing modulated intra- and extracellular ROS by enhancing antioxidant mechanism of fibroblast under oxidative stress. Finally,in vivoassays confirmed thatSpirulina-PCL helps regenerate wounds and enhance regeneration. Taken together, the results of this study indicate thatSpirulinaand nanofiber have the potential for application to cutaneous wound to facilitate skin regeneration.
Funder
Ministry of Education, Science and Technology
Subject
General Materials Science
Cited by
45 articles.
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