Anti-HMGCR Specificity of HALIP: A Confirmatory Study-Reference-Cited by-同舟云学术

Anti-HMGCR Specificity of HALIP: A Confirmatory Study

Published:2020-07-16 Issue: Volume:2020 Page:1-4
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Baucells Andrés¹^ORCID,Martínez Maria Angeles¹^ORCID,Alvarado-Cardenas Marcelo²,Mariscal Anaís¹,Martinez-Martinez Laura¹,Juárez Cándido¹^ORCID,Selva-O’Callaghan Albert²^ORCID

Affiliation:

1. Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona 08041, Spain

2. Systemic Autoimmune Diseases Unit, Hospital Vall d’Hebrón, Medicine Department, Universidad Autónoma de Barcelona, Barcelona, Spain

Abstract

A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients’ sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies.

Funder

European Regional Development Fund

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2020/6292631.pdf

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