Catalytic Synthesis and Antifungal Activity of New Polychlorinated Natural Terpenes

Author:

Ighachane Hana1,Boualy Brahim2,Ait Ali Mustapha3,Sedra My. H.14,El Firdoussi Larbi3ORCID,Lazrek Hassan Bihi1ORCID

Affiliation:

1. Laboratory of Biomolecular and Medicinal Chemistry, URAC 16, Faculty of Sciences Semlalia, Marrakech, Morocco

2. Laboratoire de Chimie et Modélisation Mathématique, Faculté Polydisciplinaire de Khouribga, Université Hassan 1er, BP 145, 25000 Khouribga, Morocco

3. Equipe de Chimie de Coordination et Catalyse, Département de Chimie, Faculté des Sciences Semlalia, Université Cadi Ayyad, BP 2390, 40001 Marrakech, Morocco

4. Laboratory of Phytopathology, Genetics and Integrated Control (LPGLI), National Institute of Agricultural Research (INRA), P.O. Box 533, Marrakesh, Morocco

Abstract

Various unsaturated natural terpenes were selectively converted to the corresponding polychlorinated products in good yields using iron acetylacetonate in combination with nucleophilic cocatalyst. The synthesized compounds were evaluated for their in vitro antifungal activity. The antifungal bioassays showed that 2c and 2d possessed significant antifungal activity against Fusarium oxysporum f. sp. albedinis (Foa), Fusarium oxysporum f. sp. canariensis (Foc), and Verticillium dahliae (Vd).

Funder

Cadi Ayyad University

Publisher

Hindawi Limited

Subject

General Engineering,General Materials Science

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